There is a similar issue on the forum which points out the Designer exception.
Although, in my case, the problem occurs when I am trying to save a layout that I previously edited in the Source tab. Whenever I try to save, those message appears.
One for asking me if I want to overwrite the actual .axml that I just modified. Seems odd to me. Then if I click on Yes, I get the following error "Microsoft Visual Studio - Connection Closed" and the file doesn't appear to be saved.
Still, I can close it without saving and reopen it, and my changes have been applied to the file. However, I found it annoying to have to executes those steps in order to save a tiny modification.
Anyone having the same issue?